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M9460695.TXT
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1994-06-25
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Document 0695
DOCN M9460695
TI Management of human papilloma virus vulvo-perineal infection with
systemic beta-interferon and thymostimulin in HIV-positive patients.
DT 9408
AU Frega A; di Renzi F; Stentella P; Pachi A; II Clinic of Obstetrics and
Gynecology, University of Rome La; Sapienza, Italy.
SO Int J Gynaecol Obstet. 1994 Mar;44(3):255-8. Unique Identifier :
AIDSLINE MED/94229320
AB OBJECTIVES: To evaluate the effect of a combined therapy based on
beta-interferon and thymostimulin in HIV-seropositive women with florid
vulvoperineal condylomatosis. METHODS: Nineteen HIV-seropositive women
affected by HPV florid vulvo-perineal infection were studied. Their ages
ranged from 19 to 32 years (mean = 26); all were smokers; 11 (57.89%)
were intravenous drug users with a mean period of drug addiction of 5
years. No patient was on AZT therapy. All patients underwent a combined
medical therapy based on beta-interferon administration with doses of
3,000,000 IU i.m. daily for 7 days and subsequently on alternate days
for 2 weeks associated with the administration of 70 mg i.m. of
thymostimulin per day on alternate days for 30 days. RESULTS: Seven
(36.84%) patients showed complete recovery at the end of follow-up; 5
(26.31%) patients showed partial recovery and 7 (36.84%) did not respond
to therapy. CONCLUSION: A pro-host immunotherapy seems to be indicated
in patients affected by immunodeficiency syndrome.
DE Adjuvants, Immunologic/THERAPEUTIC USE Adult AIDS-Related
Opportunistic Infections/MICROBIOLOGY/*THERAPY Condylomata
Acuminata/*THERAPY Female Human HIV Seropositivity/*MICROBIOLOGY
Interferon Inducers/*THERAPEUTIC USE Interferon-beta/*THERAPEUTIC USE
*Papillomavirus, Human Papovaviridae Infections/*THERAPY
Perineum/MICROBIOLOGY Substance Abuse, Intravenous/COMPLICATIONS
Thymus Extracts/*THERAPEUTIC USE Vulvar Diseases/*MICROBIOLOGY/THERAPY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).